Primal Health Databank: Study
| Entry No: | 0428 |
| Title: | Do hypertension and diuretic treatment in pregnancy increase the risk of schizophrenia in offspring? |
| Author(s): | Sorensen HJ, Mortensen EL, Reinisch JM, Mednick SA |
| Reference: | Am J Psychiatry 2003 Mar;160(3):464-8 |
| Place of Study: | Denmark |
| Abstract: | Diuretics prescribed after the first trimester for treatment of hypertension in pregnant women may interfere with normal plasma volume expansion and cause volume depletion. The authors hypothesized that prenatal exposure to diuretics and maternal hypertension might disrupt fetal neurodevelopment and increase the risk of schizophrenia in offspring. Using data from the Copenhagen Perinatal Cohort of individuals born between 1959 and 1961, the authors studied the relationship of maternal hypertension and diuretic treatment during pregnancy with the risk of schizophrenia (ICD-8 code 295) in the offspring. Prenatal medical information was linked to the Danish National Psychiatric Register. The effects of maternal hypertension and diuretic treatment were adjusted for the maternal history of schizophrenia, social status of the family breadwinner, mother's age, and concomitant drug treatment during pregnancy. In a risk set of 7,866 individuals, 84 cases of schizophrenia were found (1.1% prevalence). Logistic multiple regression analysis identified the following independent risk factors: maternal hypertension (odds ratio=1.69 [95% CI=1.02-2.80]), diuretic treatment in the third trimester (odds ratio=2.55 [95% CI=1.21-5.37]), and maternal schizophrenia (odds ratio=11.12 [95% CI=4.60-29.91]). Prenatal exposure to both hypertension and diuretic treatment in the third trimester conferred a 4.01-fold (95% CI=1.41-11.40) elevated risk. |
| Keyword(s): | diuretics, pregnancy hypertension, schizophrenia |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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