Primal Health Databank: Study
| Entry No: | 0623 |
| Title: | Birth weight and risk of breast cancer in a cohort of 106,504 women |
| Author(s): | Ahlgren M, Sorensen T, Wohlfahrt J, Haflidadottir A, Holst C, Melbye M |
| Reference: | Int J Cancer. 2003 Dec 20;107(6):997-1000 |
| Place of Study: | Denmark |
| Abstract: | The authors investigated the relationship between birth weight and risk of female breast cancer in a cohort of 106,504 Danish women. Birth weights were obtained from school health records on girls born between 1930-1975. Information on breast cancer came from linking the cohort with the Danish Cancer Registry and the Danish Breast Cancer Cooperative Groups Registry. A total of 2,334 cases of primary breast cancer were diagnosed in the cohort during 3,255,549 person-years of follow-up among women with birth weight between 500-6,000 g. Of these, 922 (40%) were diagnosed with primary breast cancer at the age of 50 years or older. A significant association between birth weight and breast cancer was found equivalent to an increase in risk of 9% per 1,000 g increase in birth weight (95% CI 2-17). The increase was observed for all age groups, representing both pre- and post-menopausal women, and irrespective of tumor characteristics. Adjustment for age at first birth and parity did not influence the results. |
| Keyword(s): | birth weight, breast cancer |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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