Primal Health Databank Entry

Entry No:0642
Title:Being born small for gestational age increases the risk of severe pre-eclampsia
Author(s):Zetterstrom K, Lindeberg S, Haglund B, Magnuson A, Hanson U, Adami HO, Trichopoulos D.
Reference:BJOG. 2007 Mar;114(3):319-24
Place of Study:Sweden
Abstract:The first aim of this study was to investigate the risk of pre-eclampsia, both mild and severe, in women born small for gestational age (SGA). The second aim was to investigate whether the risk is modified by pre-eclampsia in the previous generation. The design was a population-based cohort study. The authors looked at a population of 118 634 women registered both as newborns and as mothers in the Swedish Medical Birth Register of 1973-2003. Of these, 6883 had been born SGA. Only primiparas and singletons were included.The pregnancies that the women were born out of were analysed with regard to presence of pre-eclampsia, while their own pregnancies were analysed regarding age at delivery, smoking, body mass index and incidence of mild or severe pre-eclampsia. Multiple logistic regression analysis was used. In a first step, the authors adjusted for maternal characteristics, and in a second step, for pre-eclampsia in the previous generation. In women born SGA, the adjusted odds ratio (first step) for mild pre-eclampsia was 1.19 (95% CI 1.03-1.38), while for severe pre-eclampsia it was 1.69 (95% CI 1.40-2.02) compared with those not born SGA. After the second-step adjustment, the odds ratio for mild pre-eclampsia was 1.16 (95% CI 1.00-1.35) and for severe pre-eclampsia was 1.62 (95% CI 1.35-1.95). No statistically significant effect modification from pre-eclampsia in the previous generation was shown. Conclusions: Women born SGA suffer a markedly increased risk of severe pre-eclampsia. Exposure to pre-eclampsia during a woman's own fetal development significantly increases her risk of pre-eclampsia but does not modify the SGA effect.
Keyword(s):birthweight, eclampsia, forceps delivery, pre-eclampsia, pre-eclampsia, preeclampsia, vacuum, ventouse
Discussion:No discussion mentioned for this entry
See Also:No related entries mentioned for this entry

Go Back | New Keyword Search