Primal Health Databank Entry

Entry No:0672
Title:Outcomes at 2 years of age after repeat doses of antenatal corticosteroids
Author(s):Crowther CA, Doyle LW, Haslam RR, Hiller JE, Harding JE, Robinson JS; ACTORDS Study Group, Harding JE
Reference:N Engl J Med. 2007 Sep 20;357(12):1179-89
Place of Study:Australia
Abstract:Women who had received an initial course of corticosteroid treatment 7 or more days previously were randomly assigned to receive an intramuscular injection of corticosteroid (11.4 mg of betamethasone) or saline placebo; the dose was repeated weekly if the mother was still considered to be at risk for preterm delivery and the duration of gestation was less than 32 weeks. The authors assessed survival free of major neurosensory disability and body size of the children at 2 years of corrected age. Of the 1085 children who were alive at 2 years of age, 1047 (96.5%) were seen for assessment (521 exposed to repeat-corticosteroid treatment and 526 exposed to placebo). The rate of survival free of major disability was similar in the repeat-corticosteroid and placebo groups (84.4% and 81.0%, respectively; adjusted relative risk, 1.04, 95% confidence interval, 0.98 to 1.10; adjusted P=0.20). There were no significant differences between the groups in body size, blood pressure, use of health services, respiratory morbidity, or child behavior scores, although children exposed to repeat doses of corticosteroids were more likely than those exposed to placebo to warrant assessment for attention problems (P=0.04).
Keyword(s):ADHD, attention deficit hyperactivity disorder, corticosteroids, dexamethasone, glucocorticoids
Discussion:No discussion mentioned for this entry
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