Primal Health Databank: Study
| Entry No: | 0729 |
| Title: | Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status |
| Author(s): | Larsson HJ, Eaton WW, Madsen KM, et al., Joner G; Norwegian Childhood Diabetes Study Group, Stuver SO, Hsieh C |
| Reference: | Am J Epidemiol. 2005 May 15;161(10):916-25 |
| Place of Study: | Denmark |
| Abstract: | This case-control study explored the association between perinatal factors, parental psychiatric history, socioeconomic status, and risk of autism. The study was nested within a cohort of all children born in Denmark after 1972 and at risk of being diagnosed with autism until December 1999. Prospectively recorded data were obtained from nationwide registries in Denmark. Cases totaled 698 children with a diagnosis of autism; each case was individually matched by gender, birth year, and age to 25 controls. Analyses by conditional logistic regression produced risk ratios and 95% confidence intervals. Adjusted analyses showed that the risk of autism was associated with breech presentation (risk ratio (RR) = 1.63, 95% confidence interval (CI): 1.18, 2.26), low Apgar score at 5 minutes (RR = 1.89, 95% CI: 1.10, 3.27), gestational age at birth <35 weeks (RR = 2.45, 95% CI: 1.55, 3.86), and parental psychiatric history (schizophrenia-like psychosis: RR = 3.44, 95% CI: 1.48, 7.95; affective disorder: RR = 2.91, 95% CI: 1.65, 5.14). Analyses showed no statistically significant association between risk of autism and weight for gestational age, parity, number of antenatal visits, parental age, or socioeconomic status. |
| Keyword(s): | apgar score, autism, autistic spectrum disorder, breech presentation, labor induction, labour induction, pre-eclampsia, preeclampsia, Rhesus-immunization |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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