Primal Health Databank: Study
| Entry No: | 0806 |
| Title: | Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism. |
| Author(s): | Hallmayer J, Cleveland S, et al. |
| Reference: | Arch Gen Psychiatry. 2011 Jul 4. [Epub ahead of print] |
| Place of Study: | USA |
| Abstract: | The participants wee twin pairs with at least 1 twin with an autism spectrum disorder (ASD) born between 1987 and 2004 were identified through the California Department of Developmental Services.
Structured diagnostic assessments (Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule) were completed on 192 twin pairs. Concordance rates were calculated and parametric models were fitted for 2 definitions, 1 narrow (strict autism) and 1 broad (ASD).
For strict autism, probandwise concordance for male twins was 0.58 for 40 monozygotic pairs (95% confidence interval [CI], 0.42-0.74) and 0.21 for 31 dizygotic pairs (95% CI, 0.09-0.43); for female twins, the concordance was 0.60 for 7 monozygotic pairs (95% CI, 0.28-0.90) and 0.27 for 10 dizygotic pairs (95% CI, 0.09-0.69). For ASD, the probandwise concordance for male twins was 0.77 for 45 monozygotic pairs (95% CI, 0.65-0.86) and 0.31 for 45 dizygotic pairs (95% CI, 0.16-0.46); for female twins, the concordance was 0.50 for 9 monozygotic pairs (95% CI, 0.16-0.84) and 0.36 for 13 dizygotic pairs (95% CI, 0.11-0.60). A large proportion of the variance in liability can be explained by shared environmental factors (55%; 95% CI, 9%-81% for autism and 58%; 95% CI, 30%-80% for ASD) in addition to moderate genetic heritability (37%; 95% CI, 8%-84% for autism and 38%; 95% CI, 14%-67% for ASD).
CONCLUSION: Susceptibility to ASD has moderate genetic heritability and a substantial shared twin environmental component. |
| Keyword(s): | autism, autistic spectrum disorder, influenza, twins |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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