Primal Health Databank Entry

Entry No:0840
Title:Prenatal Exposure to Mercury and Fish Consumption During Pregnancy and Attention-Deficit/Hyperactivity Disorder-Related Behavior in Children.
Author(s):Sagiv SK, Thurston SW, et al.
Reference:Arch Pediatr Adolesc Med. 2012 Oct 8:1-9. doi: 10.1001/archpediatrics.2012.1286. [Epub ahead of print]
Place of Study:USA
Abstract: For a population-based prospective birth cohort recruited in New Bedford, Massachusetts (1993-1998), the authors analyzed data for children examined at age 8 years with peripartum maternal hair mercury measures (n = 421) or maternal report of fish consumption during pregnancy (n = 515). Inattentive and impulsive/hyperactive behaviors were assessed using a teacher rating scale and neuropsychological testing. The median maternal hair mercury level was 0.45 μg/g (range, 0.03-5.14 μg/g), and 52% of mothers consumed more than 2 fish servings weekly. In multivariable regression models, mercury exposure was associated with inattention and impulsivity/hyperactivity; some outcomes had an apparent threshold with associations at 1 μg/g or greater of mercury. For example, at 1 μg/g or greater, the adjusted risk ratios for mild/markedly atypical inattentive and impulsive/hyperactive behaviors were 1.4 (95% CI, 1.0-1.8) and 1.7 (95% CI, 1.2-2.4), respectively, for an interquartile range (0.5 μg/g) mercury increase; there was no confounding by fish consumption. For neuropsychological assessments, mercury and behavior associations were detected primarily for boys. There was a protective association for fish consumption (
Keyword(s):ADHD, attention deficit hyperactivity disorder, fish, fish consumption, mercury
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