Primal Health Databank Entry

Entry No:0881
Title:Acetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders.
Author(s):Liew Z, Ritz B, et al.
Reference:JAMA Pediatr. 2014 Feb 24. doi: 10.1001/jamapediatrics.2013.4914. [Epub ahead of print]
Place of Study:Denmark
Abstract:The authors studied 64 322 live-born children and mothers enrolled in the Danish National Birth Cohort during 1996-2002. Acetaminophen use during pregnancy was assessed prospectively via 3 computer-assisted telephone interviews during pregnancy and 6 months after child birth. To ascertain outcome information the authhors used parental reports of behavioral problems in children 7 years of age using the Strengths and Difficulties Questionnaire; retrieved HKD diagnoses from the Danish National Hospital Registry or the Danish Psychiatric Central Registry prior to 2011; and identified ADHD prescriptions (mainly Ritalin) for children from the Danish Prescription Registry. The authors estimated hazard ratios for receiving an HKD diagnosis or using ADHD medications and risk ratios for behavioral problems in children after prenatal exposure to acetaminophen. More than half of all mothers reported acetaminophen use while pregnant. Children whose mothers used acetaminophen during pregnancy were at higher risk for receiving a hospital diagnosis of HKD (hazard ratio = 1.37; 95% CI, 1.19-1.59), use of ADHD medications (hazard ratio = 1.29; 95% CI, 1.15-1.44), or having ADHD-like behaviors at age 7 years (risk ratio = 1.13; 95% CI, 1.01-1.27). Stronger associations were observed with use in more than 1 trimester during pregnancy, and exposure response trends were found with increasing frequency of acetaminophen use during gestation for all outcomes (ie, HKD diagnosis, ADHD medication use, and ADHD-like behaviors; P trend
Keyword(s):acetaminophen, ADHD, attention deficit hyperactivity disorder
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