Primal Health Databank Entry

Entry No:0909
Title:Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis.
Author(s):Gardener H, Spiegelman D, et al.
Reference:Pediatrics. 2011 Aug;128(2):344-55. doi: 10.1542/peds.2010-1036. Epub 2011 Jul 11.
Place of Study:USA
Abstract:Forty studies were eligible for the meta-analysis. For each exposure, a summary effect estimate was calculated using a random-effects model. Heterogeneity in effect estimates across studies was examined, and, if found, a meta-regression was conducted to identify measured methodological factors that could explain between-study variability. Over 60 perinatal and neonatal factors were examined. Factors associated with autism risk in the meta-analysis were abnormal presentation, umbilical-cord complications, fetal distress, birth injury or trauma, multiple birth, maternal hemorrhage, summer birth, low birth weight, small for gestational age, congenital malformation, low 5-minute Apgar score, feeding difficulties, meconium aspiration, neonatal anemia, ABO or Rh incompatibility, and hyperbilirubinemia. Factors not associated with autism risk included anesthesia, assisted vaginal delivery, postterm birth, high birth weight, and head circumference. CONCLUSIONS: There is insufficient evidence to implicate any 1 perinatal or neonatal factor in autism etiology, although there is some evidence to suggest that exposure to a broad class of conditions reflecting general compromises to perinatal and neonatal health may increase the risk. Methodological variations were likely sources of heterogeneity of risk factor effects across studies.
Keyword(s):autism, autistic spectrum disorder, labor augmentation, labour augmentation, synthetic oxytocin
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