Primal Health Databank Entry

Entry No:0924
Title:Oxytocin-augmented labor and risk for autism in males.
Author(s):Weisman O, Carter CS, et al.
Reference:Behav Brain Res. 2015 May 1;284:207-12. doi: 10.1016/j.bbr.2015.02.028. Epub 2015 Feb 20.
Place of Study:Denmark
Abstract:This is an epidemiological analysis, including all singleton live births in Denmark between 2000 and 2009 (N=557,040), with a follow-up through 2012. A total of 2110 children in this cohort were subsequently diagnosed with autistic disorder according to the ICD-10-DCR. Augmentation of labor with OT was modestly associated with an increased risk for autism in males (HR 1.13; 95% CI, 1.00-1.26; P=0.04), but not in females (0.99; 0.77-1.27; P=0.95). Among males exposed to OT augmentation, 560 were subsequently diagnosed with autistic disorder, and among those not exposed, 1177 met criteria for autism (incidence rate 103.2 and 81.4 per 100,000 person-years, respectively).
Keyword(s):autism, autistic spectrum disorder, labor augmentation, labour augmentation, synthetic oxytocin
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