Primal Health Databank Entry

Entry No:0938
Title: Preterm Birth and Poor Fetal Growth as Risk Factors of Attention-Deficit/Hyperactivity Disorder.
Author(s):Sucksdorff M, Lehtonen L, et al.
Reference:Pediatrics. 2015 Aug 24. pii: peds.2015-1043. [Epub ahead of print]
Place of Study:Finland
Abstract:In this population-based study, 10 321 patients with ADHD, diagnosed according to the International Classification of Diseases and 38 355 controls individually matched for gender, date and place of birth, were identified from Finnish nationwide registers. Perinatal data were obtained from the Finnish Medical Birth Register. Conditional logistic regression was used to examine the association between gestational age, weight for gestational age, and ADHD after controlling for confounding factors. The risk of ADHD increased by each declining week of gestation. The associations were robust after adjusting for confounders. An elevated risk also was seen among late preterm and early term infants. As for fetal growth, the odds ratio showed a U-shaped curve with an increased risk seen when the weight for gestational age was 1 SD below and 2 SD above the mean. CONCLUSIONS: These findings suggest that each gestational week has significance for child's subsequent neurodevelopment and risk for ADHD. They also showed that poor fetal growth increased the risk of ADHD. This highlights the importance of taking into account both prematurity and poor fetal growth when planning the timing of birth as well as later follow-up and support policies
Keyword(s):ADHD, attention deficit hyperactivity disorder, fetal growth retardation, gestational age, prematurity
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