Primal Health Databank: Study
| Entry No: | 1001 |
| Title: | Conception via in vitro fertilization and delivery by Caesarean section are associated with paediatric asthma incidence. |
| Author(s): | Guibas GV, Moschonis G, et al |
| Reference: | Clin Exp Allergy. 2013 Sep;43(9):1058-66. doi: 10.1111/cea.12152. |
| Place of Study: | Greece |
| Abstract: | Parent-reported wheeze in the last 12 months (current), wheeze ever, physician-diagnosed asthma, method of conception, and type of delivery were recorded from questionnaires filled in by the parents of 2016 Greek children aged 9-13, (the Healthy Growth Study population). Some perinatal data were recorded from children's medical records and others were reported by parents; anthropometric measurements were also conducted in children.
IVF was correlated with physician-diagnosed asthma (OR = 2.25; 95% CI = 1.11-4.56), but not with current/ever wheeze after adjustment for potential confounding factors. After adjustment, C-section was also associated with asthma (OR = 1.39; 95% CI = 1.04-1.87), but not with current/ever wheeze. When the association of both IVF and C-section with asthma was examined in the same multivariate logistic regression model, it was weakened to borderline significance (OR = 2.04; 95% CI = 1-4.15 and OR = 1.34; 95% CI = 1-1.81 respectively).
CONCLUSIONS AND CLINICAL RELEVANCE:
Conception via IVF and delivery by C-section may predispose children to future asthma development. Either variable could also exert a confounding effect on the link of the other to asthma; this may partially be accountable for inconsistencies in the findings of pertinent studies. |
| Keyword(s): | asthma, asthma in childhood, caesarean, cesarean, IVF, medicalised conception, medically assisted fecundation |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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